Cylindrocyclophane f
Cylindrocyclophanes are a class of cyclophane, a group of aromatic hydrocarbons composed of two benzene rings attached in a unique structure. Cylindrocyclophanes were the first cyclophanes found in nature, isolated from a species of cyanobacteria, and have proven to be an interesting … See more Before the cylindrocyclophanes, the cyclophanes had all been produced synthetically. However, when a culture of the cyanobacteria Cylindrospermum lichenforme was being evaluated for antitumor activity, … See more Cylindrocyclophanes are all [7,7] paracyclophanes, differing only in the functional groups present on C-1, C-14, C-29, and C-33. There are currently 16 cylindrocyclophanes … See more Since the cylindrocyclophanes have such a unique structure and exciting biological possibilities due to their cytotoxicity, there have been numerous efforts to create them synthetically in the laboratory. One of the first attempts was the total synthesis of cylindrocyclophane … See more When cylindrocyclophane A was discovered, it was during an evaluation of the cyanobacteria Cylindrospermum lichenforme for antitumor activity. It was shown that … See more WebJan 20, 2016 · Except for cylindrocyclophane A (25), non-carbamoylated or diacetylated [7.7]paracyclophanes (e.g., cylindrocyclophane A 1 (21) and D (27)) tended to be slightly less potent against MRSA, especially against strains N315 and Mu50 (MICs in the range 0.8‒12.9 µM) than the other derivatives, as it has been reported previously for MRSA …
Cylindrocyclophane f
Did you know?
WebA possible above-room-temperature molecular multiferroic, triethylmethylammonium tetrabromoferrate (III) (1), has been discovered. Its ferroelectric and magnetic phase transitions take place at almost the same temperature (∼360 K), resulting in strong magnetodielectric (MD) coupling, with a MD ratio of 18% at 0.6 MHz.
WebJul 10, 2013 · We have recently identified the enzymes involved in the biosynthesis of the cylindrocyclophanes, a structurally unique family of natural products, and found that this pathway employs a remarkable... WebApr 10, 1992 · Cylindrocyclophanes A-F are moderate cytotoxins associated with strains of the terrestrial blue-green alga Cylindrospermum licheniforme. The absolute …
WebMay 18, 2024 · We have reported the development of a divergent synthetic strategy for the study of novel cylindrocyclophane scaffolds. Application of this method enabled us to … WebF: R1 = R2 = H • Cylindrocyclophane A was first isolated in 1990 by Moore et al. from the blue-green algae Cylindrospermum licheniforme Kutzing. • Cylindrocyclophane B-F were later isolated in 1992 again by Moore et al. • This class of compounds has been found to be biologically active showing moderate cytotoxicity against several tumor ...
WebCylK 4 nostcyclophane and merocyclophane natural products. (b) Cylindrocyclophane F is synthesized through head-to-tail dimerization of (S,R)-1catalyzed by CylK. In this article, we report the crystal structures of CylK in its apo form …
WebOct 18, 2024 · CylK is the key enzyme to catalyze the formation of the cylindrocyclophane scaffold through the Friedel-Crafts alkylation reactions with regioselectivity and stereospecificity. Further research... inches of h2oWebNov 13, 2024 · A short and efficient total synthesis of the C 2-symmetric (-)-cylindrocyclophane F is presented, using a cross olefin metathesis dimerization strategy … inches of h2o to psigWebCylindrocyclophane F was isolated using a procedure adapted from Moore and co-workers.2 Freeze-dried C. licheniforme ATCC 29412 (1.36 g) was ground using a mortar and pestle and the resulting paste was suspended in 7:3 ethanol/water (500 mL) and stirred overnight at 4 ºC. Insoluble cell debris was removed by centrifugation (4,000 rpm x 10 … inches of fish per gallonWebCylindrocyclophane F C36H56O4 - PubChem compound Summary Cylindrocyclophane F Cite Download Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical … incoming transition planWebThe structures of the ketones 1004 and 1006 are analogous to the p-cyclophane 992 in Scheme 7.4, and all react to give the hydrocarbons 1005 and 1007 in good yields (5).The … inches of h2o to psi conversionWebSep 18, 2024 · The cylindrocyclophanes and nostocyclophanes were discovered on the basis of antitumor activity showed by two Nostocales cyanobacterial extracts.38 The bioassay-guided isolation led to the structure elucidations of cylindrocyclophane A (16) and halogenated nostocyclophane D (17), from Cylindrospermum licheniforme ATTC … incoming trayWebThe cylindrocyclophanes are a family of macrocyclic natural products reported to exhibit antibacterial activity. Little is known about the structural basis of this activity due to the challenges associated with their synthesis or isolation. inches of hg to h20