Fixed dose rasburicase

Author: uxnn

August undefined, 2024

WebRasburicase is a recombinant urate oxidase enzyme approved for use in tumor lysis syndrome (TLS) and it acts by reducing serum uric acid levels. Using rasburicase at the recommended dose of... WebEvaluation of a single fixed dose of rasburicase 7.5 mg for the treatment of hyperuricemia in adults with cancer. Pharmacotherapy. 2008;28(6):685–690. 23. Rényi I, Bárdi E, Udvardi E, et al. Prevention …

Rasburicase in the management of tumor lysis: an …

WebJun 1, 2011 · It is concluded that a single 3-mg dose of rasburicase, used with close monitoring, is sufficient to treat most adults with uric acid levels up to 12 mg/dL, and continues to decline beyond 24 h in most patients without additional treatment. Rasburicase was administered at a fixed dose of 3 mg to treat 287 episodes of elevated serum uric … WebRasburicase injection is used to treat high levels of uric acid (a natural substance that builds up in the blood as tumors break down) in people with certain types of cancer who … data factory bearer token

Rasburicase - an overview ScienceDirect Topics

WebRasburicase Elitek Antihyperuricemic agent Injection: 1.5, 7.5 mg; contains mannitol and L-alanine Hyperuricemia (all ages): 0.1–0.2 mg/kg/dose (rounded down to the nearest whole 1.5 mg multiple) IV over 30 min × 1. Patients generally respond to one dose but if needed dose may be repeated Q 24 hr for up to four additional doses. WebBackground: Fixed-dose rasburicase (FDR) is common practice in treating hyperuricemia associated with tumor lysis syndrome in adults; however, there is a lack of data regarding the effectiveness of this dosing strategy specifically in the overweight and obese patient populations. Objective: To determine if patient weight per body mass index (BMI) … WebOur results demonstrate that a single fixed dose of rasburicase 3 mg, repeated if required, should be the standard regimen in the management of TLS. Recent studies and published guidelines have shown cumulative … bitmap image to word

Rasburicase Dosage Guide + Max Dose, Adjustments

Hyperuricemia Management - The Journal of Hematology …

WebNov 25, 2016 · We conducted separate analyses for fixed single doses ranging from 1·5 to 7·5 mg and weight-based single doses. Outcomes of the same dosing groups were pooled together and then compared with data extracted from the other dosage groups. ... Single-dose rasburicase is efficient in lowering UA level and in preventing and treating children … WebThe only patient who did not respond to the single 6-mg rasburicase dose was a morbidly obese man (259 kg, body mass index 87 kg/m2) who subsequently responded to an additional dose of rasburicase 12 mg. These results warrant further investigation of a single 6-mg dose of rasburicase in adults with TLS or at high-risk for developing TLS. bitmap in asp.net coreWebThe labeled dose is 0.2 mg/kg/day administered intravenously over 30 minutes for up to 5 days. Our institutional adult guidelines recommend rasburicase 6 mg for uric acid levels … bitmap in android

"WebRasburicase dosing was at the discretion of the treating clinician, and the initial dose ranged from 1.5 to 16.5 mg. Nine patients had uric acid levels above the normal range … " - Fixed dose rasburicase

Fixed dose rasburicase

The efficacy and cost-impact of rasburicase 3 mg versus 6 mg for …

Webwww.ncbi.nlm.nih.gov WebDec 3, 2015 · Based on the average wholesale price of $815 for one 1.5 mg vial of rasburicase, the single 3 mg dose was associated with …

Did you know?

Webfixed dosing strategies have also been described.1-7 Based on a Rasburicase MUE presented at the February 2015 P&T meeting, the following criteria are proposed: 1. Flat … WebFeb 8, 2024 · Rasburicase: recombinant uricase that catalyzes the breakdown of uric acid to allantoin Indications and dosing Treatment of established TLS: rasburicase infusion . Prophylaxis for intermediate to high-risk patients: rasburicase infusion OR single fixed-dose rasburicase G6PD deficiency hemolytic anemia Urinary alkalinization

WebMar 1, 2011 · The current recommended dose is 0.2 mg/kg/day administered intravenously with the first dose given prior to chemotherapy. ... Shanholtz CB, Thompson JL. Fixed-dose rasburicase 6 mg for hyperuricemia and tumor lysis syndrome in high-risk cancer patients. Ann Pharmacother. 2010;44:1529-1537. Uric acid as a weak organic acid (pka 5.8) is … WebExpert guidelines by Coieffer et al. 7 in 2008 and Cairo et al. in 2010 1 on the management of TLS recommend a rasburicase dose of 0.1–0.2 mg kg −1 on the first day, then repeated for up to 7 days 1 or as necessary 7. …

WebControl subjects received a single 0.15-mg/kg dose of rasburicase. Measurements and main results: Uric acid levels were measured in all patients at baseline, at 12 and 24 hours after dosing, and then daily. In all patients receiving 7.5 mg, uric acid levels returned to normal at 12 and 24 hours. WebApr 15, 2013 · Rasburicase is a recombinant urate-oxidase enzyme approved by the Food and Drug Administration in 2002 for the treatment of hyperuricemia in patients receiving …

WebJun 13, 2005 · Rasburicase is a recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma. …

WebLearn more about the nature of hyperuricemia and its various treatment options. data factory binary copyWebOur findings demonstrated that a single 6-mg fixed dose of rasburicase is effective in preventing or managing hyperuricemia in patients at high risk for TLS and maintaining … bitmap in computingWebMost of the data for single-dose rasburicase are retrospective reviews based on single-institution experiences using fixed doses of rasburicase ranging from 1.5 to 7.5 mg, 11-13 and 1 prospective study using a historical control group. 14 Repeat doses may be given based on continued serum uric acid level monitoring. 11,12 data factory batch countWebJan 10, 2024 · Rasburicase is a recombinant urate oxidase enzyme used for the treatment and prevention of tumor lysis syndrome. Our objective was to assess the efficacy of … data factory billingWebRasburicase should not be administered to patients receiving continuous dialysis. Bulky disease and chemo sensitive malignancies increase the risk of TLS. These situations … bitmap index exampleWebFeb 18, 2014 · The median uric acid level reduction 24 h post rasburicase dose 1.5 mg, 3 mg, 4.5 mg, and 6 mg were 5.5, 5.8, 3.8, and 10.05 mg/dL, respectively. There was no … bitmapinfoheader infoheadWebJan 20, 2024 · Rasburicase Dosage Medically reviewed by Drugs.com. Last updated on Jan 20, 2024. Applies to the following strengths: 1.5 mg; 7.5 mg Usual Adult Dose for: … data factory binary dataset