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WebYra žinoma, kad transkripcijos faktoriaus interferono reguliavimo faktorius 8 (IRF8) reguliuoja imuninių ląstelių diferenciaciją ir funkciją. Čia autoriai rodo, kad žmogaus ir pelių hipertrofinėje širdyje IRF8 yra reguliuojamas, kai jis slopina širdies remodeliavimą slopindamas kalcineurino signalizaciją. Web1 Jan 2014 · IRF8 suppresses Ang II-induced cardiomyocyte hypertrophy Decreased IRF8 expression in response to hypertrophic stimuli implies a potential role for IRF8 in the regulation of pathological cardiac hypertrophy. To test this hypothesis, we performed gain- and loss-of-function studies in NRCMs. forward therapy midland mi
Anti-IkB-α (phospho-S32/S36) Antibody (A27385) Antibodies.com
WebJoin or sign in to find your next job. Join to apply for the Substance Use Navigator, Full Time, Evening Shift-8 Hr, Emergency Department/Grants role at Adventist Health WebDescription Rabbit polyclonal antibody to IkB-α (phospho-S32/S36) Specificity p-IκB-α (S32+S36) pAb detects endogenous levels of IκB-α protein only when phosphorylated at Ser32+S36. Applications WB, IHC, IF Reactivity Human, Mouse, Rat Immunogen Synthetic phosphopeptide derived from human IkB-α around the phosphorylation site of Serine … Web2 Nov 2016 · IRF8 activation is up-regulating autophagy and M1 polarization of macrophages after AGEs (advanced glycation endproducts) treatment, blocking the IRF8 with shIRF8 inhibits autophagic activity and M1 polarization. In summary, this study elucidates that AGEs induces autophagy and modulates macrophage polarization to M1 … directions to halifax shopping centre